TRANSLATIONAL PHYSIOLOGY Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia
نویسندگان
چکیده
D. L. Shawcross,* S. Balata,* S. W. M. Olde Damink, P. C. Hayes, J. Wardlaw, I. Marshall, N. E. P. Deutz, R. Williams, and R. Jalan Liver Failure Group, Institute of Hepatology, University College London, London, WC1E 6HX United Kingdom; The Scottish Liver Transplantation Unit, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW; Department of Surgery, Academic Hospital, Maastricht University, 6229 HX Maastricht, The Netherlands; Division of Clinical Sciences, Western General Hospital, Edinburgh EH4 2XU; and Department of Medical Physics, University of Edinburgh, Edinburgh EH3 9YW, Scotland
منابع مشابه
Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia.
The neuropsychological effect of hyperammonemia is variable. This study tests the hypothesis that the effect of ammonia on the neuropsychological function in patients with cirrhosis is determined by the ability of the brain to buffer ammonia-induced increase in glutamine within the astrocyte by losing osmolytes like myo-inositol (mI) and not by the magnitude of the induced hyperammonemia. Fourt...
متن کاملLow myo-inositol and high glutamine levels in the brain are associated with neuropsychological deterioration following induced hyperammonemia
Background: The neuropsychological effect of hyperammonemia is variable. This study tests the hypothesis that the effect of ammonia on the neuropsychological function in patients with cirrhosis is determined by the ability of the brain to ‘buffer’ ammonia-induced increase in glutamine within the astrocyte by losing osmolytes like myo-inositol (mI) and not by the magnitude of the ‘induced hypera...
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